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Biosensing Instrument
Biosensing Instrument公司使用獨特的SPR(表面電將共振)檢測方法來實現高靈敏度和快速檢測。創新的設計和BI-DirectFlow™技術使我們能夠將小體積的精確樣品輸送與漂移消除技術結合起來,以滿足用戶的對於蛋白質或小分子藥物結合特性分析的各種應用需求。此外,我們新穎的模塊化設計使用戶能夠輕鬆執行各種應用,例如電化學,氣相SPR與顯微影像SPR。
- 產品系列
- 應用實例
SPRm 200
表面電漿共振顯微鏡
表面電漿共振顯微鏡(SPRm)系統結合了光學顯微鏡和SPR技術,是一種用於體外測量細胞上膜蛋白結合力(包含蛋白與小分子)的強大技術,一反需要使用純物質進行結合利研究的技術。它允許通過明場顯微鏡同時測量細胞樣品的表型變化,並通過SPR同時測量結合強度和動力學。
- 儀器規格:
- SPR光源波長: 690nm
- 明視野影像與SPR訊號自動整合
- 偵測視野: 600x450 um
- 解析度: 1um
- 解離偵測範圍: KD = 10-3 M (1 mM) to 10-12 M (1 pM)
- 產品應用:
- 藥物篩選
- 分子結合動力分析
- 膜蛋白功能研究
- 結合與解離常數測定
- 活細胞SPR即時量測(貼附以及懸浮細胞)
- 腫瘤Glycan異質性分析
- 抗體在細胞上的Avidity & Affinity分析




Curious on what the 5-channel BI-4500 SPR can do for you?
Biosensing Instrument's BI-4500 SPR, featuring 5 channels, enhances throughput, accelerates result acquisition, and allows for more versatile assays. It is also capable of analyzing complex biological samples and studying multiple analyte-ligand interactions in a single run.
This new application note highlights the BI-4500's performance in high-throughput, real-time binding analysis, with a focus on its utility in drug discovery and diagnostic testing. The first study demonstrates the system's ability to measure the binding of various small molecule analytes to carbonic anhydrase II. The second study showcases how the 5-channel system can immobilize different ligands across the channels, enabling the measurement of binding interactions between COVID-19-related antibodies and viral particles in serum samples.